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KMID : 0351219930250030211
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Korean Journal of Infectious Diseases
1993 Volume.25 No. 3 p.211 ~ p.219
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change of Serum beta2-Microglobulin, p24 Antigen and CD4+ T Lymphocyte in persons with Human Immunodeficiency Virus Infection after Azidothymidine Treatment
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Abstract
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The effect of azidothymidine (AZT) in 48 HIV-infected patients taking AZT was evaluated by CD4+ T lymphocyte counts, serum β2-microglobulin (β2 -MG), and p24 antigen levels. The results were also compared with the group without AZT. Annual
decrease of
CD4+ T lymphocyte counts was 70 cells/μL in group without AZT Tx and 38 cell/ μL in group with AZT Tx. Response rate of CD4+ T lymphocyte counts to AZT Tx was 77% within 2 months, 68% within 2 to 6 months, 41% within 6 to 12 months and 31%
within
12
to 24 months after AZT Tx. The level of β2-MG dropped from 2.95*1.45mg/L at 2.2 months before Tx to 2.87*0.9mg/L at 2.4 months after Tx, and then increased to 3.05*1.11mg/L at 7.4*4.4 months after AZT Tx. HIV p24 antigen was detected in
26(14.9%)
of
174 persons with HIV infection. p24 antigen level tested within 2 months after AZT Tx decreased in 9(69%) of 13 patients receiving Tx. And p24 antigen level showed sigmficant decrease from 11.2*11.2 pg/ml to 5.6*3.2 pg/ml at 1.8*0.8 months after
AZT Tx
(p<0.01) and then increase to 18.4*18.5 pg/ml at 6.2*3.2 months after Tx (p<0.01). The data indicate that drug resistance to AZT gradually develops within one year after AZT Tx.
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KEYWORD
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